Rx
Generic Elavil®

Amitriptyline HCl

4.8
26,564 Nurx Reviews
Based on all Nurx reviews, not any one product

Amitriptyline HCl is an antidepressant that may be prescribed to treat major depressive disorder and chronic pain.

Depression Icon Depression
Pill Icon Pill

$25/month

As low as $0/month with insurance

Medication shipped and billed every 1 or 3 months.
This treatment requires an online consultation with a Nurx medical provider. Cost may vary based on your insurance coverage, price not guaranteed. Not all insurance plans are accepted. Medication costs vary based on prescribed treatment and applicable insurance coverage and are shipped and billed separately as a 1-month or 3-month supply. Additional costs may apply, including a support fee and ongoing care fee.

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How amitriptyline HCl treats depression*

  • Influences serotonin and norepinephrine in your brain
  • Improves focus, sleep, and mood
  • May help reduce pain
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Did you know?

21 million US adults

have experienced at least one major depressive episode

Real patient stories

The science behind it

Fact 01

Impacts neurotransmitters

This medicine works by affecting norepinephrine and serotonin levels in your brain.

Fact 02

Tricyclic antidepressant

This type of medication is named for its chemical structure, which has three rings.

Fact 03

Improves physical symptoms

While first taking this medication, most people notice fewer physical symptoms related to depression.

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How to use amitriptyline HCl

It can take several weeks or longer for your emotional symptoms to respond to treatment.

Drug facts

STEP 1

Take as prescribed by your provider.

STEP 2

May be taken with or without food.

STEP 3

Depending on how you respond to treatment, your provider may recommend adjusting your dosage.

How Nurx works

1

Request treatment

Complete our online medical consultation, which asks questions about your health history and mental health symptoms.

2

Connect with a provider

After evaluating your consultation, a provider licensed in your state will prescribe treatment (if clinically appropriate).

3

Get it delivered

We’ll send a 1 or 3-month supply to your doorstep and check in with you to see how it’s working. Pause or cancel anytime.

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100%

online care

2+ million

Nurx patients served

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Why Nurx?

Affordable

Quality treatment at an attainable price

Convenient

Easy refills & shipping to your door

Personalized

Providers help you find the right treatment

Supportive

Unlimited messaging for any questions, anytime

Common questions

  • What is amitriptyline HCl?

    Amitriptyline HCl is a prescription medication used to treat a variety of conditions, including major depressive disorder and chronic pain. It’s a tricyclic antidepressant that affects norepinephrine and serotonin levels in your brain. If you have a depression-related condition that isn’t responding to lifestyle changes or more common medications like SSRIs (selective serotonin reuptake inhibitors), amitriptyline might be right for you.

  • How does amitriptyline HCl work?

    Amitriptyline HCl is part of a class of drugs called tricyclic antidepressants. It influences serotonin and norepinephrine in your brain. These are chemicals that help you maintain focus, sleep better, have positive thoughts, and improve your mood. Tricyclic antidepressants are typically used for depression. They may also be used to reduce pain.

  • What are the side effects of amitriptyline HCl?

    The side effects of amitriptyline HCl include drowsiness, constipation, fatigue, and dry mouth. Since amitriptyline HCl is a tricyclic antidepressant (TCA), other common side effects include nausea and headaches. In addition to these possible adverse reactions from taking amitriptyline, there may be risks for people who have certain medical conditions or take other medications.

  • How do I take amitriptyline HCl?

    Amitriptyline HCl comes in pill form and is usually taken one to four times per day. Take amitriptyline HCl around the same time(s) every day, and do not take more or less than prescribed by your provider. If you’re taking amitriptyline long-term, your provider will likely start you off with a low dose to make sure there are no negative side effects. Once things settle out, they can increase your dosage if it seems appropriate. If you plan to stop using amitriptyline HCl, let your provider know as this medication should not be stopped abruptly and you may need to taper your dose to discontinue it.

  • Can I take amitriptyline HCl with other medications?

    Before you take amitriptyline HCl, be sure to talk with your provider about all of your current medications. Certain substances are known to interact dangerously with amitriptyline. If you are currently taking any medications or supplements, discuss them carefully with your provider before adding amitriptyline to your treatment plan. The provider who prescribed amitriptyline HCl will likely have some recommendations for combining it with other medications.

  • Are there any risks when taking amitriptyline HCl?

    Like any medication, amitriptyline HCl does come with some risks. Talk to your provider about the risks of taking this medication if you are 65 years of age or older. Tell your provider if you have recently had a heart attack, are pregnant, plan to become pregnant or are currently breastfeeding. You’ll also want to limit your intake of alcohol if you’re taking amitriptyline HCl, and avoid driving or operating heavy machinery while taking this medication.

  • How quickly does amitriptyline HCl work?

    Within a few days of starting on amitriptyline HCl, you may notice improvements in your mood and energy levels. At first, most people taking amitriptyline notice that they have fewer physical symptoms related to depression. However, it can take several weeks or longer for your emotional symptoms to respond to treatment.

Please note: Nurx does not provide therapy or counseling. Nurx is not available for crisis response. If you are experiencing a mental health crisis, please contact 911 or go to your nearest emergency department. IF YOU ARE CONTEMPLATING SUICIDE, CONTACT 911 OR CALL/TEXT THE NATIONAL SUICIDE PREVENTION LINE AT 988. These services are available 24/7.

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DR. GABRIELLA FARKAS, MEDICAL DIRECTOR

Meet your medical team

Gabriella Farkas, MD PhD is the Medical Director for Nurx’s mental health services. Dr. Farkas is a board-certified psychiatrist who advises the Nurx medical team on how to provide the highest quality of care for mental health conditions through telehealth.

†Amitriptyline HCl tablets (10mg, 25mg, 50mg, 75mg, 100mg, & 150mg), Rx only, treats depression. Amitriptyline HCl may cause side effects, including fatigue, constipation, dry mouth, dry eyes, bleeding. If you would like to learn more ,see full prescribing information, here. You are encouraged to report negative side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
*Individual results may vary.
‡The information provided here is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided here for specific medical advice. If you have any questions or concerns, please talk to your provider.
◊Nurx does not provide talk therapy or crisis management. Services not offered in every state. Medications prescribed only if clinically appropriate, based on completion of the required consultation.

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Exceptional care at every step

At Nurx, we make it easy to get the expert healthcare you deserve. From schedules to health history, everybody is different—so we provide treatment and care that’s personalized to you. Through life’s cycles, changes, and transitions, we’re here to help you make informed choices about your health.

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