Compounded vs Brand-Name GLP-1 Drugs: What’s Right For Me?
Medically reviewed by Dr. Hayley Miller, Medical Director, Weight Management on April 15, 2025
GLP-1 medications have revolutionized weight management care, and with good reason. They work. In fact, 2023 marked the first time in over a decade that adult obesity rates in the US declined, a shift partially attributed to the increased availability and use of GLP-1 medications.
With over 38 million Americans living with diabetes and more than 40% of the population affected by obesity, demand for these medications has skyrocketed. The downside? Shortages have made it tough to find brand-name options in pharmacies nationwide.
If you’re considering GLP-1 treatment, you might have heard about compounded versions as an alternative. But are they safe? Do they work the same way? And how do they compare to FDA-approved medications?
Let’s break it down so you can make the most informed decision for your health.
What are GLP-1 drugs?
GLP-1 medications mimic glucagon-like peptide-1 (GLP-1)—a natural hormone in your body that helps regulate appetite, blood sugar, and digestion. Some medications also target glucose-dependent insulinotropic peptide (GIP) for additional effects on metabolism.
These medications were originally developed to treat diabetes, but their weight loss effects ultimately led to FDA approval for treatment of obesity under different brand names (more on this below).
GLP-1 medications vary in their frequency of use and the hormone receptors they target.
What are brand-name GLP-1 drugs?
Brand-name GLP-1 medications—like Ozempic®, Wegovy®, and Mounjaro®—are developed, patented, and sold by pharmaceutical companies. These medications go through a rigorous FDA approval process to ensure their safety and efficacy before they are accessible to patients. Because they are mass-manufactured under strict regulations, every dose is produced with the same consistency and quality.
The medications have different names based on FDA approval for specific conditions. Although they contain the same active ingredient, one brand-name version is approved for diabetes treatment, while the other is designated for treating obesity. Consider Wegovy® (approved for obesity treatment) and Ozempic® (approved for treatment of Type 2 Diabetes)—these are identical medications (containing semaglutide), just marketed under different names depending on their intended use.
What are compounded GLP-1 drugs?
If brand-name GLP-1 medications are in short supply, compounded versions may be an alternative. Under certain circumstances, compounding pharmacies may create compounded GLP-1s with the same active ingredient as brand-name versions. These medications can be used to help bridge the gap during shortages.
It’s important to know that compounded GLP-1 medications are NOT FDA-approved, meaning they haven’t undergone the same rigorous testing for safety and efficacy as the brand-name medications. Because they’re not mass-produced under strict pharmaceutical regulations, the quality and consistency can vary depending on the pharmacy preparing them. However, they tend to be more accessible and can be tailored to meet individual dosing needs.
Understanding the key differences between brand-name and compounded GLP-1 drugs
Understanding the differences between brand-name and compounded GLP-1 medications is essential to making an informed decision. Here’s what you need to know:
FDA Approval
Brand-name GLP-1 medications undergo years of rigorous research, clinical trials, and FDA evaluation before becoming available for prescription. This helps to ensure their safety, effectiveness, and consistency.
In contrast, compounded GLP-1 medications are not FDA-approved, meaning their quality and reliability are not guaranteed. If you’re considering a compounded option, it’s essential to choose a reputable pharmacy that sources ingredients from credible suppliers. Additionally, selecting a pharmacy that conducts third-party testing for quality and safety can provide an extra layer of assurance.
Availability and Accessibility
Brand-name GLP-1 medications can be difficult to access, especially during shortages. Compounded alternatives may offer a more readily available option, but they should only be prescribed by a qualified, licensed provider and sourced from a thoroughly vetted pharmacy to ensure safety and quality.
Pricing
One of the biggest barriers to brand-name GLP-1 medications is cost. Without insurance, these medications can start at around $1000 or more. Some pharmaceutical companies offer coupons, but eligibility varies. Compounded GLP-1s are often more affordable, starting at around $179 per month. However, they are not covered by insurance.
Conclusion
Choosing between brand-name and compounded GLP-1 medications depends on your individual needs, access, and budget. If you’re considering a compounded option, it’s critical to work with a trusted provider and a reputable pharmacy to ensure safety and effectiveness. The good news? Nurx offers both! Our dedicated weight management providers are here to guide you through your options and help you find the best fit for your journey.
DISCLAIMERS
Services and treatments not offered in every state, include medical treatment of overweight and obesity including lifestyle counseling (e.g., diet and exercise) and prescription medications, if clinically appropriate, based on completion of required consultation. Nurx requires regular check-ins to monitor your progress. Weight loss may be associated with other symptoms including but not limited to muscle loss, fatigue, menstrual changes, gallstones, and mood changes. Extreme/rapid weight loss may result in nutritional deficiencies that lead to hair loss, anemia, weak bones or increased risk of infection. Talk to your provider immediately about symptoms. Many people with overweight or obesity who lose weight have a tendency to regain all or some of the weight over time. Overweight and obesity medication efficacy increases with the addition of diet and exercise. Individual response to treatment may vary and is not guaranteed by Nurx.
Compounded drugs are not FDA-approved or evaluated for safety, efficacy, or quality. Nurx weight management compound drug offerings are not available to patients in California or Hawaii.
