Rx
Generic Differin®

Adapalene Gel 0.3%

Adapalene is a retinoid that may be prescribed to treat acne.

Acne Icon Acne
Topical gel Icon Topical gel

$30/month

As low as $0/mo with insurance

Medication costs vary based on prescribed treatment and applicable insurance coverage. Not all insurance plans are accepted. Additional costs apply, including a consultation and support fee. Medication shipped and billed every 3 months. One tube of medication contains a 3-month supply.
This treatment requires an online consultation with a Nurx medical provider. If prescribed, they'll check in to ensure your treatment is working.*

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How adapalene treats acne*

  • Promotes faster healing of existing pimples
  • Stimulates cell growth to control the formation of new acne breakouts
  • Minimizes swelling and inflammation
Find my treatment
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DID YOU KNOW?

Acne is the most common skin condition in the US.

Real patient stories

Side-by-side images depict a woman's face before and after using Tretinoin Cream for acne treatment. Left: acne visible on cheek. Right: clear skin with closed eyes, highlighting the cream's effectiveness.
REAL RESULTS

Shannon, Nurx patient

Side-by-side comparison of a person with acne on the left and clearer skin on the right, highlighting the transformative effects of Tretinoin Cream. Both images show the person wearing glasses and facing the camera, showcasing their journey towards healthier skin.
REAL RESULTS

Nathalia, Nurx patient

The science behind it

FACT 01

Stimulates cell growth

By speeding up skin cell turnover, adapalene helps unclog pores and decrease the formation of new pimples.

FACT 02

Promotes faster healing

Adapalene can help existing acne heal faster.

Fact 03

Anti-inflammatory benefits

This medication also may help reduce swelling and redness for active acne breakouts.

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How to use adapalene

Consistency is key to maximizing the effectiveness of your acne treatment.

Drug facts

Step 1

Each night, gently cleanse your skin and pat dry.

Step 2

Spread a thin layer of gel onto the affected area.

Step 3

If needed, apply moisturizer to calm irritation and dryness.

How Nurx works

1

Request treatment

Complete our online medical consultation, which asks questions about your health history and skin concerns.

2

Connect with a provider

After evaluating your consultation, a provider licensed in your state will prescribe treatment (if clinically appropriate).

3

Get it delivered

We’ll send a 3-month supply to your doorstep and check in with you to see how it’s working. Pause or cancel anytime.

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100%

online expert-level care

2+ million

Nurx patients served

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Why Nurx?

Affordable

Quality treatment at an attainable price

Convenient

Easy refills & shipping to your door

Personalized

Providers help you find the right treatment

Supportive

Unlimited messaging for any questions, anytime

Common questions

  • How does adapalene work?

    Adapalene helps to control the formation of new acne breakouts and speed the healing of existing pimples. However, it is not a cure for acne and must be used continuously to control this condition. During the first 8 to 12 weeks of use, adapalene may cause acne to worsen, as it brings existing pimples to the surface to begin the healing process. It is important to continue using adapalene for several months to assess the full potential of this medication.

    You should follow the directions on the packaging exactly for any adapalene product unless otherwise directed by your provider. Do not attempt to increase or reduce usage without first contacting your healthcare provider.

  • How long does it take to see results from adapalene?

    Adapalene may cause your acne to worsen before it improves. This is because the retinoid brings pimples and imperfections to the surface. Since pimples can take four to six weeks to form, you may have developing breakouts under the surface of your skin that weren't visible when you began using adapalene. After about a month of continuous use, you may begin to see results. However, some will not see notable results until they've used adapalene consistently for three months.

  • What happens when you stop using adapalene?

    If you discontinue the use of adapalene before it has a chance to work properly, your acne may worsen. It's best to discuss your skincare with a healthcare provider before you choose to stop using adapalene to determine if a different application frequency or concentration of this medication will give you better results.

  • Does adapalene remove dark spots?

    Adapalene has been used by some as an anti-aging product. There is some evidence that it can help reduce the appearance of dark spots. Adapalene may also help reduce the appearance of fine lines and brighten dull skin. If you plan to use adapalene for purposes other than acne control, you should speak with your healthcare provider about the best way to incorporate this product into your skincare routine.

  • Can I use adapalene every day?

    Yes, you should use adapalene daily to get the best results. You should apply adapalene before bed, as you should not apply makeup or other products on top of the adapalene medication. Unless otherwise advised, the best method of application is to:
    - Gently cleanse your skin with a mild soap. Do not scrub vigorously, as this can irritate the skin and worsen sensitivities that are already caused by adapalene. Pat dry with a soft clean towel.
    - Gently spread a thin layer of adapalene over the affected area. Apply adapalene to the entire area that's affected rather than a single pimple or small patch of irritation.
    - Apply a moisturizer to the affected area if needed to calm irritation and dryness. This is optional.

  • What precautions should I take when using adapalene?

    Many skin care products can cause irritation if used along with adapalene, so it's best to discuss all products you're using with your Nurx provider before you add adapalene to your skin care regimen. You will likely experience a reaction if you use adapalene with skin care products that contain:
    - Alcohol
    - Lime rind
    - Sulfur
    - Salicylic acid
    - Glycolic acid
    - Alpha hydroxy acid
    - Spices

    You should avoid any unnecessary exposure to sunlight while using adapalene. Wear protective clothing that covers as much skin as possible, and always use a sunscreen with an SPF of 30 or higher. Exposure to cold or wind may cause irritation when you're taking adapalene. Avoid exposure to tanning beds or other forms of artificial light. You should not use hot wax for hair removal while you're using adapalene.

    When using adapalene, you should avoid contact with the eyes, nose, lips, and mucous membranes.

    The effectiveness of adapalene has not been assessed for patients under the age of 12 or over the age of 65.

  • Does adapalene have any known side effects?

    Side effects associated with adapalene are usually worst during the first month of treatment and will typically lessen with time. The most common effects are:
    - Stinging or burning
    - Scaling
    - Dry skin
    - Erythema (redness)

    Using a moisturizer will typically reduce the severity of these side effects.

    Other common side effects include:
    - Itching
    - Sunburn
    - Peeling
    - Brief warming sensation after application
    Less common side effects that may occur with adapalene are:
    - Eczema
    - Rash
    - Acne flare
    - Contact dermatitis
    Serious but uncommon side effects may include:
    - Intense burning
    - Eyelid swelling
    - Skin discoloration
    - Red, watering eyes
    - Very irritated or red skin

    If you experience serious side effects with adapalene or have any form of irritation that is too severe to manage, you should consult your healthcare provider. Your provider may recommend that you reduce the frequency of use or discontinue using adapalene entirely.

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DR. PETER YOUNG, MEDICAL DIRECTOR

Meet your medical team

Peter Young, MD is the Medical Director for Nurx’s Dermatology specialty. Dr. Young is a board-certified dermatologist who advises the Nurx medical team on how to provide the highest quality of care for dermatology conditions through telehealth.

†Adapalene gel 0.3%, Rx only, treats acne vulgaris. This drug may cause side effects, including stinging or burning, scaling, dry skin, and erythema (redness). If you would like to learn more ,see full prescribing information here. You are encouraged to report negative side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
*Individual results may vary.
‡The information provided here is not a substitute for professional medical advice, diagnosis, or treatment. You should not rely upon the content provided here for specific medical advice. If you have any questions or concerns, please talk to your provider.
◊Services not offered in every state. Medications prescribed only if clinically appropriate, based on completion of the required consultation.

Talk to our experts

Not sure if this medication is right for you?

Connect with a Nurx provider for a personalized treatment recommendation.

Exceptional care at every step

At Nurx, we make it easy to get the expert healthcare you deserve. From schedules to health history, everybody is different—so we provide treatment and care that’s personalized to you. Through life’s cycles, changes, and transitions, we’re here to help you make informed choices about your health.

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